Alum impairs tolerogenic properties induced by allergoid‐mannan conjugates inhibiting mTOR and metabolic reprogramming in human DCs

BACKGROUND: Polymerized allergoids conjugated to mannan (PM) are suitable vaccines for allergen‐specific immunotherapy (AIT). Alum remains the most widely used adjuvant in AIT, but its way of action is not completely elucidated. The better understanding of the mechanisms underlying alum adjuvanticit...

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Bibliographic Details
Published in:Allergy
Main Authors: Benito‐Villalvilla, Cristina, Soria, Irene, Pérez‐Diego, Mario, Fernández‐Caldas, Enrique, Subiza, José Luis, Palomares, Oscar
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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ORIGINAL ARTICLES
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079174/
https://ncbi.nlm.nih.gov/pubmed/31494959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.14036
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