Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment

BACKGROUND: The mechanism of resistance development to anti-VEGF therapy in ovarian cancer is unclear. We focused on the changes in tumour immunity post anti-VEGF therapy. METHODS: The frequencies of immune cell populations and hypoxic conditions in the resistant murine tumours and clinical samples...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Horikawa, Naoki, Abiko, Kaoru, Matsumura, Noriomi, Baba, Tsukasa, Hamanishi, Junzo, Yamaguchi, Ken, Murakami, Ryusuke, Taki, Mana, Ukita, Masayo, Hosoe, Yuko, Koshiyama, Masafumi, Konishi, Ikuo, Mandai, Masaki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078258/
https://ncbi.nlm.nih.gov/pubmed/31932754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0725-x
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