Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

Snail is a major transcriptional factor that induces epithelial-mesenchymal transition (EMT). In this study, we explore the effect of Snail on tumor immunity. Snail knockdown in mouse ovarian cancer cells suppresses tumor growth in immunocompetent mice, associated with an increase of CD8(+) tumor-in...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Taki, Mana, Abiko, Kaoru, Baba, Tsukasa, Hamanishi, Junzo, Yamaguchi, Ken, Murakami, Ryusuke, Yamanoi, Koji, Horikawa, Naoki, Hosoe, Yuko, Nakamura, Eijiro, Sugiyama, Aiko, Mandai, Masaki, Konishi, Ikuo, Matsumura, Noriomi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923228/
https://ncbi.nlm.nih.gov/pubmed/29703902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03966-7
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