Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene

Loss-of-function mutations in the solute carrier organic anion transporter family, member 2a1 gene (SLCO2A1), which encodes a prostaglandin (PG) transporter, have been identified as causes of chronic nonspecific multiple ulcers in the small intestine; however, the underlying mechanisms have not been...

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Publicado en:Sci Rep
Autores principales: Nakata, Rieko, Nakamura, Yoshinobu, Hosomi, Shuhei, Okuda, Hiroaki, Nishida, Yu, Sugita, Naoko, Itani, Shigehiro, Nadatani, Yuji, Otani, Koji, Tanaka, Fumio, Kamata, Noriko, Taira, Koichi, Nagami, Yasuaki, Tanigawa, Tetsuya, Watanabe, Toshio, Yamagami, Hirokazu, Nakanishi, Takeo, Fujiwara, Yasuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078201/
https://ncbi.nlm.nih.gov/pubmed/32184453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61775-9
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