Cross-reactive antigen expressed by B6 splenocytes drives receptor editing and MZ differentiation of IgG2a-reactive AM14 Vκ8 B cells

The AM14 BCR, derived from an autoimmune MRL/lpr mouse, binds autologous IgG2a(a/j) with low affinity, and as a result AM14 B cells only proliferate in response to IgG2a immune complexes that incorporate DNA, RNA, or nucleic acid binding proteins that serve as autoadjuvants. As such, AM14 B cells ha...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Nündel, Kerstin, Mande, Purvi, Moses, Stephanie L., Busto, Patricia, Cullen, Jaime L., Schmidt, Madelyn R., Shlomchik, Mark J., Woodland, Robert T., Marshak-Rothstein, Ann
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078032/
https://ncbi.nlm.nih.gov/pubmed/31534009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900499
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge