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Cross-reactive antigen expressed by B6 splenocytes drives receptor editing and MZ differentiation of IgG2a-reactive AM14 Vκ8 B cells
The AM14 BCR, derived from an autoimmune MRL/lpr mouse, binds autologous IgG2a(a/j) with low affinity, and as a result AM14 B cells only proliferate in response to IgG2a immune complexes that incorporate DNA, RNA, or nucleic acid binding proteins that serve as autoadjuvants. As such, AM14 B cells ha...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7078032/ https://ncbi.nlm.nih.gov/pubmed/31534009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900499 |
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