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The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells

The protein kinase Btk has been implicated in the development, differentiation, and activation of B cells through its role in the BCR and TLR signaling cascades. These receptors and in particular, the BCR and either TLR7 or TLR9 also play a critical role in the activation of autoreactive B cells by...

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Detalhes bibliográficos
Main Authors: Nündel, Kerstin, Busto, Patricia, Debatis, Michelle, Marshak-Rothstein, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800065/
https://ncbi.nlm.nih.gov/pubmed/23804807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0313126
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