Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy

Botulinum neurotoxins (BoNTs) are a family of bacterial toxins with seven major serotypes (BoNT/A–G). The ability of these toxins to target and bind to motor nerve terminals is a key factor determining their potency and efficacy. Among these toxins, BoNT/B is one of the two types approved for medica...

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Udgivet i:PLoS Biol
Main Authors: Yin, Linxiang, Masuyer, Geoffrey, Zhang, Sicai, Zhang, Jie, Miyashita, Shin-Ichiro, Burgin, David, Lovelock, Laura, Coker, Shu-Fen, Fu, Tian-min, Stenmark, Pål, Dong, Min
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077807/
https://ncbi.nlm.nih.gov/pubmed/32182233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000618
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