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Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy
Botulinum neurotoxins (BoNTs) are a family of bacterial toxins with seven major serotypes (BoNT/A–G). The ability of these toxins to target and bind to motor nerve terminals is a key factor determining their potency and efficacy. Among these toxins, BoNT/B is one of the two types approved for medica...
में बचाया:
| में प्रकाशित: | PLoS Biol |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Public Library of Science
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7077807/ https://ncbi.nlm.nih.gov/pubmed/32182233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000618 |
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