LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

OBJECTIVES: The concept of trained innate immunity describes a long-term proinflammatory memory in innate immune cells. Trained innate immunity is regulated through reprogramming of cellular metabolic pathways including cholesterol and fatty acid synthesis. Here, we have analyzed the role of Liver X...

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Pubblicato in:Front Immunol
Autori principali: Sohrabi, Yahya, Sonntag, Glenn V. H., Braun, Laura C., Lagache, Sina M. M., Liebmann, Marie, Klotz, Luisa, Godfrey, Rinesh, Kahles, Florian, Waltenberger, Johannes, Findeisen, Hannes M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077358/
https://ncbi.nlm.nih.gov/pubmed/32210962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00353
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