The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites

Higher expression of the human DNA repair enzyme MUTYH has previously been shown to be strongly associated with reduced survival in a panel of 24 human lymphoblastoid cell lines exposed to the alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). The molecular mechanism of MUTYH-enhanced MNN...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Raetz, Alan G., Banda, Douglas M., Ma, Xiaoyan, Xu, Gege, Rajavel, Anisha N., McKibbin, Paige L., Lebrilla, Carlito B., David, Sheila S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076218/
https://ncbi.nlm.nih.gov/pubmed/32001618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010497
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