Evidence for Abasic Site Sugar Phosphate-Mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces cerevisiae

To better understand alkylating agent-induced cytotoxicity and the base lesion DNA repair process in Saccharomyces cerevisiae, we replaced the RAD27(FEN1) open reading frame (ORF) with the ORF of the bifunctional human repair enzyme DNA polymerase (Pol) β. The aim was to probe the effect of removal...

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Bibliographic Details
Main Authors: Heacock, Michelle, Poltoratsky, Vladimir, Prasad, Rajendra, Wilson, Samuel H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483300/
https://ncbi.nlm.nih.gov/pubmed/23144716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047945
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