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Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break
We explored DNA metabolic events potentially relevant to somatic hypermutation (SHM) of immunoglobulin genes using a yeast model system. Double-strand break (DSB) formation has been discussed as a possible component of the SHM process during immunoglobulin gene maturation. Yet, possible mechanisms l...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023910/ https://ncbi.nlm.nih.gov/pubmed/20828826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.08.013 |
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