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When you’re strange: Unusual features of the MUTYH glycosylase and implications in cancer

MUTYH is a base-excision repair glycosylase that removes adenine opposite 8-oxoguanine (OG). Variants of MUTYH defective in functional activity lead to MUTYH-associated polyposis (MAP), which progresses to cancer with very high penetrance. Whole genome and whole exome sequencing studies have found M...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Raetz, Alan G., David, Sheila S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812671/
https://ncbi.nlm.nih.gov/pubmed/31203172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.05.005
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