A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2)

The Src homology phosphatase 2 (SHP2) is a cytoplasmic enzyme that mediates signaling induced by multiple receptor tyrosine kinases, including signaling by the epidermal growth factor receptor (EGFR) family (EGFR1–4 or the human homologs HER1–4). In EGFR (HER1) and EGFR2 (HER2) signaling, SHP2 incre...

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Vydáno v:J Biol Chem
Hlavní autoři: Hartman, Zachary, Geldenhuys, Werner J., Agazie, Yehenew M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076199/
https://ncbi.nlm.nih.gov/pubmed/32024694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011422
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