A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2)

Eitemau Tebyg

• Novel Small-Molecule Inhibitor for the Oncogenic Tyrosine Phosphatase SHP2 with Anti-Breast Cancer Cell Effects
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  Cyhoeddwyd: (2020)
• Molecular Mechanism for SHP2 in Promoting HER2-induced Signaling and Transformation
  gan: Zhou, Xiangdong, et al.
  Cyhoeddwyd: (2009)
• The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration
  gan: Hartman, Zachary R., et al.
  Cyhoeddwyd: (2013)
• HER2 Stabilizes EGFR and Itself by Altering Autophosphorylation Patterns in a Manner That Overcomes Regulatory Mechanisms and Promotes Proliferative and Transformation Signaling
  gan: Hartman, Zachary, et al.
  Cyhoeddwyd: (2012)
• The Signaling and Transformation Potency of the Overexpressed HER2 Protein is Dependent on the Normally-Expressed EGFR
  gan: Zhou, Xiangdong, et al.
  Cyhoeddwyd: (2011)