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The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration

The Src homology phosphotyrosyl phosphatase2 (SHP2) is a positive effector of receptor tyrosine kinases (RTKs) signaling. Furthermore, SHP2 is known to promote cell migration and invasiveness, key steps in cancer metastasis. To date, however, the mechanism by which SHP2 regulates cell movement is no...

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書誌詳細
主要な著者: Hartman, Zachary R., Schaller, Michael D., Agazie, Yehenew M.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686999/
https://ncbi.nlm.nih.gov/pubmed/23512980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0578
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