Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

Patients with Systemic lupus erythematosus (SLE) experience various peripheral and central nervous system manifestations including spatial memory impairment. A subset of autoantibodies (DNRAbs) cross-react with the GluN2A and GluN2B subunits of the NMDA receptor (NMDAR). We find that these DNRAbs ac...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Chan, Kelvin, Nestor, Jacquelyn, Huerta, Tomás S., Certain, Noele, Moody, Gabrielle, Kowal, Czeslawa, Huerta, Patricio T., Volpe, Bruce T., Diamond, Betty, Wollmuth, Lonnie P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075964/
https://ncbi.nlm.nih.gov/pubmed/32179753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15224-w
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