Design, Synthesis, and Anti-RNA Virus Activity of 6′-Fluorinated-Aristeromycin Analogues

[Image: see text] The 6′-fluorinated aristeromycins were designed as dual-target antiviral compounds aimed at inhibiting both the viral RNA-dependent RNA polymerase (RdRp) and the host cell S-adenosyl-l-homocysteine (SAH) hydrolase, which would indirectly target capping of viral RNA. The introductio...

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Publicado en:J Med Chem
Autores principales: Yoon, Ji-seong, Kim, Gyudong, Jarhad, Dnyandev B., Kim, Hong-Rae, Shin, Young-Sup, Qu, Shuhao, Sahu, Pramod K., Kim, Hea Ok, Lee, Hyuk Woo, Wang, Su Bin, Kong, Yun Jeong, Chang, Tong-Shin, Ogando, Natacha S., Kovacikova, Kristina, Snijder, Eric J., Posthuma, Clara C., van Hemert, Martijn J., Jeong, Lak Shin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2019
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075649/
https://ncbi.nlm.nih.gov/pubmed/31244113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00781
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