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Altered Brain Metabolome Is Associated with Memory Impairment in the rTg4510 Mouse Model of Tauopathy

Alzheimer’s disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau leads to neurodegeneration and cogni...

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Foilsithe in:Metabolites
Main Authors: Tondo, Mireia, Wasek, Brandi, Escola-Gil, Joan Carles, de Gonzalo-Calvo, David, Harmon, Clinton, Arning, Erland, Bottiglieri, Teodoro
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7074477/
https://ncbi.nlm.nih.gov/pubmed/32075035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo10020069
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