Altered Brain Metabolome Is Associated with Memory Impairment in the rTg4510 Mouse Model of Tauopathy

Alzheimer’s disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau leads to neurodegeneration and cogni...

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Detalhes bibliográficos
Principais autores: Mireia Tondo, Brandi Wasek, Joan Carles Escola-Gil, David de Gonzalo-Calvo, Clinton Harmon, Erland Arning, Teodoro Bottiglieri
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-02-01
coleção:Metabolites
Assuntos:
metabolomics
alzheimer’s disease
tauopathy
rtg4510 mice
cognitive impairment
Acesso em linha:https://www.mdpi.com/2218-1989/10/2/69
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