SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K

[Image: see text] Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective for AAK1/BMP2K over other NAK family members, demonstrates narrow act...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wells, Carrow, Couñago, Rafael M., Limas, Juanita C., Almeida, Tuanny L., Cook, Jeanette Gowen, Drewry, David H., Elkins, Jonathan M., Gileadi, Opher, Kapadia, Nirav R., Lorente-Macias, Alvaro, Pickett, Julie E., Riemen, Alexander, Ruela-de-Sousa, Roberta R., Willson, Timothy M., Zhang, Cunyu, Zuercher, William J., Zutshi, Reena, Axtman, Alison D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073879/
https://ncbi.nlm.nih.gov/pubmed/32184967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00399
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