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CG200745, a Novel HDAC Inhibitor, Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome

Histone deacetylases have been a target of therapy for organ fibrosis. Here, we report the protective effect of CG200745 (CG), a novel histone deacetylase inhibitor, on tubulointerstitial fibrosis in Col4a3(−/−) mice, a murine model of Alport syndrome. Morphological analyses revealed CG treatment ma...

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Bibliografski detalji
Izdano u:Int J Mol Sci
Glavni autori: Suh, Sang Heon, Choi, Hong Sang, Kim, Chang Seong, Kim, In Jin, Cha, Hyunju, Cho, Joong Myung, Ma, Seong Kwon, Kim, Soo Wan, Bae, Eun Hui
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073208/
https://ncbi.nlm.nih.gov/pubmed/32098220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041473
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