A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance

Pancreatic cancer is predominantly lethal, and is primarily treated using gemcitabine, with increasing resistance. Therefore, novel agents that increase tumor sensitivity to gemcitabine are needed. Histone deacetylase (HDAC) inhibitors are emerging therapeutic agents, since HDAC plays an important r...

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Publicado no:Sci Rep
Main Authors: Lee, Hee Seung, Park, Soo Been, Kim, Sun A, Kwon, Sool Ki, Cha, Hyunju, Lee, Do Young, Ro, Seonggu, Cho, Joong Myung, Song, Si Young
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278546/
https://ncbi.nlm.nih.gov/pubmed/28134290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41615
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