Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ

Despite the wide use of angiotensin II receptor blockers in the treatment of Alport syndrome (AS), the mechanism as to how angiotensin II receptor blockers prevent interstitial fibrosis remains unclear. Here, we report that treatment of olmesartan effectively targets the feedback loop between the re...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Suh, Sang Heon, Choi, Hong Sang, Kim, Chang Seong, Kim, In Jin, Ma, Seong Kwon, Scholey, James W., Kim, Soo Wan, Bae, Eun Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695622/
https://ncbi.nlm.nih.gov/pubmed/31390839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20153843
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