Loss of 5′-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness

The 5’-methylthioadenosine phosphorylase (MTAP) gene is located in the chromosomal region 9p21. MTAP deletion is a frequent event in a wide variety of human cancers; however, its biological role in tumorigenesis remains unclear. The purpose of this study was to characterize the MTAP expression profi...

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Veröffentlicht in:Cells
Hauptverfasser: de Menezes, Weder Pereira, Silva, Viviane Aline Oliveira, Gomes, Izabela Natália Faria, Rosa, Marcela Nunes, Spina, Maria Luisa Corcoll, Carloni, Adriana Cruvinel, Alves, Ana Laura Vieira, Melendez, Matias, Almeida, Gisele Caravina, da Silva, Luciane Sussuchi, Clara, Carlos, da Cunha, Isabela Werneck, Hajj, Glaucia Noeli Maroso, Jones, Chris, Bidinotto, Lucas Tadeu, Reis, Rui Manuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072758/
https://ncbi.nlm.nih.gov/pubmed/32093414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020492
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