Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

Identification of predictive biomarkers for targeted therapies requires information on drug exposure at the target site as well as its effect on the signaling context of a tumor. To obtain more insight in the clinical mechanism of action of protein kinase inhibitors (PKIs), we studied tumor drug con...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Labots, Mariette, Pham, Thang V., Honeywell, Richard J., Knol, Jaco C., Beekhof, Robin, de Goeij-de Haas, Richard, Dekker, Henk, Neerincx, Maarten, Piersma, Sander R., van der Mijn, Johannes C., van der Peet, Donald L., Meijerink, Martijn R., Peters, Godefridus J., van Grieken, Nicole C.T., Jiménez, Connie R., Verheul, Henk M.W.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072422/
https://ncbi.nlm.nih.gov/pubmed/32024067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020330
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