INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

Identifying hyperactive kinases in cancer is crucial for individualized treatment with specific inhibitors. Kinase activity can be discerned from global protein phosphorylation profiles obtained with mass spectrometry‐based phosphoproteomics. A major challenge is to relate such profiles to specific...

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Bibliografiska uppgifter
I publikationen:Mol Syst Biol
Huvudupphovsmän: Beekhof, Robin, van Alphen, Carolien, Henneman, Alex A, Knol, Jaco C, Pham, Thang V, Rolfs, Frank, Labots, Mariette, Henneberry, Evan, Le Large, Tessa YS, de Haas, Richard R, Piersma, Sander R, Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk MW, Jimenez, Connie R
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Methods
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461034/
https://ncbi.nlm.nih.gov/pubmed/30979792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188250
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