INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

Identifying hyperactive kinases in cancer is crucial for individualized treatment with specific inhibitors. Kinase activity can be discerned from global protein phosphorylation profiles obtained with mass spectrometry‐based phosphoproteomics. A major challenge is to relate such profiles to specific...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Beekhof, Robin, van Alphen, Carolien, Henneman, Alex A, Knol, Jaco C, Pham, Thang V, Rolfs, Frank, Labots, Mariette, Henneberry, Evan, Le Large, Tessa YS, de Haas, Richard R, Piersma, Sander R, Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk MW, Jimenez, Connie R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461034/
https://ncbi.nlm.nih.gov/pubmed/30979792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188250
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