INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

Identifying hyperactive kinases in cancer is crucial for individualized treatment with specific inhibitors. Kinase activity can be discerned from global protein phosphorylation profiles obtained with mass spectrometry‐based phosphoproteomics. A major challenge is to relate such profiles to specific...

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Vydáno v:Mol Syst Biol
Hlavní autoři: Beekhof, Robin, van Alphen, Carolien, Henneman, Alex A, Knol, Jaco C, Pham, Thang V, Rolfs, Frank, Labots, Mariette, Henneberry, Evan, Le Large, Tessa YS, de Haas, Richard R, Piersma, Sander R, Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk MW, Jimenez, Connie R
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Methods
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461034/
https://ncbi.nlm.nih.gov/pubmed/30979792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188250
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