Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence

Adenoid cystic carcinoma (ACC) is an uncommon malignancy of the salivary glands that is characterized by local recurrence and distant metastasis due to its resistance to conventional therapy. Platinum-based therapies have been extensively explored as a treatment for ACC, but they show little effecti...

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Publicat a:Stem Cell Res
Autors principals: Almeida, Luciana O., Guimarães, Douglas M., Martins, Manoela D., Martins, Marco A.T., Warner, Kristy A., Nör, Jacques E., Castilho, Rogerio M., Squarize, Cristiane H.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071815/
https://ncbi.nlm.nih.gov/pubmed/28426972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2017.04.003
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