Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma

PURPOSE: There are no effective treatment options for patients with advanced adenoid cystic carcinoma (ACC). Here, we evaluated the effect of a new small molecule inhibitor of the MDM2-p53 interaction (MI-773) in preclinical models of ACC. EXPERIMENTAL DESIGN: To evaluate the anti-tumor effect of MI...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Warner, Kristy A., Nör, Felipe, Acasigua, Gerson A., Martins, Manoela D., Zhang, Zhaocheng, McLean, Scott A., Spector, Matthew E., Chepeha, Douglas B., Helman, Joseph, Wick, Michael J., Moskaluk, Christopher A., Castilho, Rogerio M., Pearson, Alexander T., Wang, Shaomeng, Nör, Jacques E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947417/
https://ncbi.nlm.nih.gov/pubmed/26936915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1698
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