Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence

Adenoid cystic carcinoma (ACC) is an uncommon malignancy of the salivary glands that is characterized by local recurrence and distant metastasis due to its resistance to conventional therapy. Platinum-based therapies have been extensively explored as a treatment for ACC, but they show little effecti...

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Main Authors: Luciana O. Almeida, Douglas M. Guimarães, Manoela D. Martins, Marco A.T. Martins, Kristy A. Warner, Jacques E. Nör, Rogerio M. Castilho, Cristiane H. Squarize
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017-05-01
Series:Stem Cell Research
Assuntos:
Adenoid cystic carcinoma
Cancer stem cells
Chemoresistance
Vorinostat
Cisplatin
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S1873506117300697
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