Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing. We examined the impact of itraconazole on ibrutinib pharmacokinetics. In a randomized crosso...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Transl Sci
Prif Awduron: Tapaninen, Tuija, Olkkola, Aleksi M., Tornio, Aleksi, Neuvonen, Mikko, Elonen, Erkki, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070818/
https://ncbi.nlm.nih.gov/pubmed/31664782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12716
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