Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing. We examined the impact of itraconazole on ibrutinib pharmacokinetics. In a randomized crosso...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Tapaninen, Tuija, Olkkola, Aleksi M., Tornio, Aleksi, Neuvonen, Mikko, Elonen, Erkki, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070818/
https://ncbi.nlm.nih.gov/pubmed/31664782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12716
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