The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer

Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)‐endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6,...

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Bibliografiska uppgifter
I publikationen:Clin Transl Sci
Huvudupphovsmän: Nardin, Jeanine Marie, Schroth, Werner, Almeida, Thais Abreu, Mürdter, Thomas, Picolotto, Solane, Vendramini, Evelyn Castillo Lima, Hoppe, Reiner, Kogin, Jenifer Primon, Miqueleto, Diandra, de Moraes, Silvia Dark Robaskievicz, Schwab, Matthias, Pecoits‐Filho, Roberto Flavio, Brauch, Hiltrud, Casali‐da‐Rocha, José Claudio
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070802/
https://ncbi.nlm.nih.gov/pubmed/31573754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12707
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