Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen

Purpose: Prediction of impaired tamoxifen (TAM) to endoxifen metabolism may be relevant to improve breast cancer treatment, e.g., via TAM dose increase. The polymorphic cytochrome P450 2D6 (CYP2D6) strongly determines an individual’s capacity for endoxifen formation, however, CYP2D6 phenotype assign...

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Udgivet i:Front Pharmacol
Main Authors: Schroth, Werner, Winter, Stefan, Mürdter, Thomas, Schaeffeler, Elke, Eccles, Diana, Eccles, Bryony, Chowbay, Balram, Khor, Chiea C., Tfayli, Arafat, Zgheib, Nathalie K., Eichelbaum, Michel, Schwab, Matthias, Brauch, Hiltrud
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609540/
https://ncbi.nlm.nih.gov/pubmed/28955222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00582
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