Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen

Purpose: Prediction of impaired tamoxifen (TAM) to endoxifen metabolism may be relevant to improve breast cancer treatment, e.g., via TAM dose increase. The polymorphic cytochrome P450 2D6 (CYP2D6) strongly determines an individual’s capacity for endoxifen formation, however, CYP2D6 phenotype assign...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Schroth, Werner, Winter, Stefan, Mürdter, Thomas, Schaeffeler, Elke, Eccles, Diana, Eccles, Bryony, Chowbay, Balram, Khor, Chiea C., Tfayli, Arafat, Zgheib, Nathalie K., Eichelbaum, Michel, Schwab, Matthias, Brauch, Hiltrud
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609540/
https://ncbi.nlm.nih.gov/pubmed/28955222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00582
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