Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen

Purpose: Prediction of impaired tamoxifen (TAM) to endoxifen metabolism may be relevant to improve breast cancer treatment, e.g., via TAM dose increase. The polymorphic cytochrome P450 2D6 (CYP2D6) strongly determines an individual’s capacity for endoxifen formation, however, CYP2D6 phenotype assign...

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Publicado en:Front Pharmacol
Autores principales: Schroth, Werner, Winter, Stefan, Mürdter, Thomas, Schaeffeler, Elke, Eccles, Diana, Eccles, Bryony, Chowbay, Balram, Khor, Chiea C., Tfayli, Arafat, Zgheib, Nathalie K., Eichelbaum, Michel, Schwab, Matthias, Brauch, Hiltrud
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609540/
https://ncbi.nlm.nih.gov/pubmed/28955222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00582
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