The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer

Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)‐endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6,...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Nardin, Jeanine Marie, Schroth, Werner, Almeida, Thais Abreu, Mürdter, Thomas, Picolotto, Solane, Vendramini, Evelyn Castillo Lima, Hoppe, Reiner, Kogin, Jenifer Primon, Miqueleto, Diandra, de Moraes, Silvia Dark Robaskievicz, Schwab, Matthias, Pecoits‐Filho, Roberto Flavio, Brauch, Hiltrud, Casali‐da‐Rocha, José Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070802/
https://ncbi.nlm.nih.gov/pubmed/31573754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12707
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