Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer

Tamoxifen is a standard endocrine therapy for the prevention and treatment of steroid hormone receptor-positive breast cancer. Tamoxifen requires enzymatic activation by CYP 450 enzymes for the formation of clinically relevant metabolites, 4-OH-tamoxifen and endoxifen, which both have a greater affi...

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Main Authors: Brauch, Hiltrud, Schroth, Werner, Eichelbaum, Michel, Schwab, Matthias, Harbeck, Nadia
Format: Artigo
Jezik:Inglês
Izdano: S. Karger GmbH 2008
Teme:
Review Article · Übersichtsarbeit
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931018/
https://ncbi.nlm.nih.gov/pubmed/20824020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000114642
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