The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

The Aurora B abscission checkpoint delays cytokinesis until resolution of DNA trapped in the cleavage furrow. This process involves PKCε phosphorylation of Aurora B S227. Assessing if this PKCε-Aurora B module provides a more widely exploited genome-protective control for the cell cycle, we show Aur...

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Vydáno v:Nat Commun
Hlavní autoři: Kelly, Joanna R., Martini, Silvia, Brownlow, Nicola, Joshi, Dhira, Federico, Stefania, Jamshidi, Shirin, Kjaer, Svend, Lockwood, Nicola, Rahmen, Khondaker Miraz, Fraternali, Franca, Parker, Peter J., Soliman, Tanya N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070073/
https://ncbi.nlm.nih.gov/pubmed/32170202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15163-6
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