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PKCɛ switches Aurora B specificity to exit the abscission checkpoint

The ‘NoCut', or Aurora B abscission checkpoint can be activated if DNA is retained in the cleavage furrow after completion of anaphase. Checkpoint failure leads to incomplete abscission and a binucleate outcome. These phenotypes are also observed after loss of PKCɛ in transformed cell models. H...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pike, Tanya, Brownlow, Nicola, Kjaer, Svend, Carlton, Jeremy, Parker, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192180/
https://ncbi.nlm.nih.gov/pubmed/28004745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13853
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