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PKCɛ switches Aurora B specificity to exit the abscission checkpoint
The ‘NoCut', or Aurora B abscission checkpoint can be activated if DNA is retained in the cleavage furrow after completion of anaphase. Checkpoint failure leads to incomplete abscission and a binucleate outcome. These phenotypes are also observed after loss of PKCɛ in transformed cell models. H...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5192180/ https://ncbi.nlm.nih.gov/pubmed/28004745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13853 |
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