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Comprehensive fitness maps of Hsp90 show widespread environmental dependence
Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes encoding 14,160 amino acid variants in Hsp90 and...
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| I publikationen: | eLife |
|---|---|
| Huvudupphovsmän: | , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
eLife Sciences Publications, Ltd
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7069724/ https://ncbi.nlm.nih.gov/pubmed/32129763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53810 |
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