Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents

The intracellular polymerization and the concomitant sickling processes, central to the pathology of sickle cell disease, can be mitigated by increasing the oxygen affinity of sickle hemoglobin (HbS). Attempts to develop azolylacryloyl derivatives to covalently interact with βCys93 and destabilize t...

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Veröffentlicht in:Medchemcomm
Hauptverfasser: Omar, A. M., David, T., Pagare, P. P., Ghatge, M. S., Chen, Q., Mehta, A., Zhang, Y., Abdulmalik, O., Naghi, A. H., El-Araby, M. E., Safo, M. K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2019
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069400/
https://ncbi.nlm.nih.gov/pubmed/32206236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00291j
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