Identification of a Novel Class of Covalent Modifiers of Hemoglobin as Potential Antisickling Agents

Aromatic aldehydes and ethacrynic acid (ECA) exhibit antipolymerization properties that are beneficial for sickle cell disease therapy. Based on ECA pharmacophore and its atomic interaction with hemoglobin, we designed and synthesized several compounds--designated as KAUS (imidazolylacryloyl derivat...

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Vydáno v:Org Biomol Chem
Hlavní autoři: Omar, A. M., Mahran, M. A., Ghatge, M. S., Chowdhury, N., Bamane, F. H. A., El-Araby, M. E., Abdulmalik, O., Safo, M. K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447584/
https://ncbi.nlm.nih.gov/pubmed/25974708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob00367a
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