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Identification of a Novel Class of Covalent Modifiers of Hemoglobin as Potential Antisickling Agents
Aromatic aldehydes and ethacrynic acid (ECA) exhibit antipolymerization properties that are beneficial for sickle cell disease therapy. Based on ECA pharmacophore and its atomic interaction with hemoglobin, we designed and synthesized several compounds--designated as KAUS (imidazolylacryloyl derivat...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4447584/ https://ncbi.nlm.nih.gov/pubmed/25974708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob00367a |
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