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Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, K(I) = 60 and 70 nM, with improved specificity over medically relevant glycosidases, making them promising candidates for controlling blood glucose. Crystallographic analysis confirmed...
Shranjeno v:
| izdano v: | Chem Sci |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Royal Society of Chemistry
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7069248/ https://ncbi.nlm.nih.gov/pubmed/32206255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc02610j |
| Oznake: |
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