Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer's Disease

BACKGROUND: Activated microglia with macrophage-like functions invade and surround β-amyloid (Aβ) plaques in Alzheimer's disease (AD), possibly contributing to the turnover of Aβ, but they can also secrete proinflammatory factors that may be involved in the pathogenesis of AD. Microglia are kno...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neurodegener Dis
Egile Nagusiak: Biscaro, Barbara, Lindvall, Olle, Tesco, Giuseppina, Ekdahl, Christine T., Nitsch, Roger M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: S. Karger AG 2012
Gaiak:
Original Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068786/
https://ncbi.nlm.nih.gov/pubmed/22584394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000330363
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