Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer's Disease

BACKGROUND: Activated microglia with macrophage-like functions invade and surround β-amyloid (Aβ) plaques in Alzheimer's disease (AD), possibly contributing to the turnover of Aβ, but they can also secrete proinflammatory factors that may be involved in the pathogenesis of AD. Microglia are kno...

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Detaylı Bibliyografya
Yayımlandı:Neurodegener Dis
Asıl Yazarlar: Biscaro, Barbara, Lindvall, Olle, Tesco, Giuseppina, Ekdahl, Christine T., Nitsch, Roger M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: S. Karger AG 2012
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068786/
https://ncbi.nlm.nih.gov/pubmed/22584394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000330363
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