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Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

BACKGROUND: The molecular mechanism underlying progressive memory loss in Alzheimer’s disease is poorly understood. Neurogenesis in the adult hippocampus is a dynamic process that continuously changes the dentate gyrus and is important for hippocampal plasticity, learning and memory. However, whethe...

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Dettagli Bibliografici
Pubblicato in:Mol Neurodegener
Autori principali: Hollands, Carolyn, Tobin, Matthew Kyle, Hsu, Michael, Musaraca, Kianna, Yu, Tzong-Shiue, Mishra, Rachana, Kernie, Steven G., Lazarov, Orly
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591545/
https://ncbi.nlm.nih.gov/pubmed/28886753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0207-7
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