Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways

Large-conductance and Ca(2+)-activated K(+) (BK) channels are expressed in human hepatic stellate cells (HSCs), where they have roles in normal hepatic microcirculation, as well as in portal hypertension in liver cirrhosis through the regulation of contractility in activated HSCs. Nevertheless, whet...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Front Pharmacol
मुख्य लेखकों: Yang, Linli, Han, Bo, Zhang, Man, Wang, Ya-Hui, Tao, Kun, Zhu, Michael X., He, Kunyan, Zhang, Zhi-Gang, Hou, Shangwei
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Media S.A. 2020
विषय:
Pharmacology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068464/
https://ncbi.nlm.nih.gov/pubmed/32210801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00165
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