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Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-β, Smad3 and JAK-STAT pathway

In order to find the possible mechanism of Dexamethasone (Dex) during curing fibrosis, the bleomycin (BLM)-induced mice model was used. After fibrosis were induced by BLM, histopathological evaluation and RT-PCR were employed to detect the expression of TGF-β1, Smad3 and STAT1. It was found that BLM...

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Détails bibliographiques
Auteurs principaux: Shi, Keyun, Jiang, Jianzhong, Ma, Tieliang, Xie, Jing, Duan, Lirong, Chen, Ruhua, Song, Ping, Yu, Zhixin, Liu, Chao, Zhu, Qin, Zheng, Jinxu
Format: Artigo
Langue:Inglês
Publié: e-Century Publishing Corporation 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211771/
https://ncbi.nlm.nih.gov/pubmed/25356121
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